Some Windows Vista users are annoyed by running Microsoft Narrator, but they don't know how to disable it.
Steps

Step 1. Click "Start" - "Control Panel"

Step 2. Click on "Accessibility"

Step 3. Click on "Screen Optimization"

Step 4. Uncheck the "Enable Narrator" and "Enable Audio Description" checkboxes

Step 5. Click OK and close the Control Panel
After restarting your computer, Narrator will no longer launch.